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In the context of diabetes, chronic hyperglycemia overwhelms the mitochondrial electron transport chain, leading to increased ROS production [176]

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If personnel take pyridostigmine in advance of exposure, soman will be prevented from binding to a significant percentage of available synaptic AChE because the AChE binding sites will be transiently occupied by pyridostigmine, and so irreversible soman aging (formation of a covalent bond) to the enzyme cannot take place