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Compared with untreated controls, microsomal protein concentrations were increased after twenty-eight days of treatment in C57BL mice, after four and twenty-eight days of treatment in C3H mice, after four days of treatment in B6C3F1 mice, and with no effect of treatment in C3B6F1 mice

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Valproic acid is associated with increasing changes in sex hormone concentrations that causes hyperandrogenism and polycystic changes regardless if the patient has epilepsy, especially in women who have gained weight or those who start valproic acid at age less than 20 years

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