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Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS) Healthcare providers are strongly encouraged to complete a REMS compliant education program and to counsel patients and caregivers on serious risks, safe use, and the importance of reading the Medication Guide with each prescription [see WARNINGS]

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Aging Cell , 20(2), e13314

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Seek immediate medical attention if you experience: marked hyperglycemia (persistent glucose 300 mg/dL), dehydration, confusion, vomiting, unexplained weight loss, excessive urination, extreme thirst, or signs of diabetic ketoacidosis (abdominal pain, rapid breathing, fruity breath odor)