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The lower manufacturing cost does give Lilly greater pricing flexibility, and the potential for eventual generic competition (small molecules follow a simpler generic approval pathway than biosimilar peptides) could drive prices down significantly over the long term

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Endotoxemia Lipopolysaccharide (LPS) is a major component of the outer membrane of all gram-negative bacteria that can trigger the synthesis and release of pro-inflammatory cytokines such as TNF, interleukin 1 (IL-1), and inducible nitric oxide synthase (iNOS) (Zhang et al., 2000

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