However, there are potential side effects, which are mild and temporary
40 The toxicity of MTX was associated with an increased expression of the proinflammatory cytokines, eg, IL6, due to the increased production of ROS and lipid peroxidation
Indeed, the most recognized effect of NO on skeletal muscle metabolism is its capacity to directly inhibit mitochondrial electron transport chain complexes: NO inhibits electron transfer and NADH-dehydrogenase function at the level of Complex I through the intra-mitochondrial production of ONOO [67]
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