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Redox imbalance: Copper-bound -syn exhibits oxidase-like activity, catalyzing dopamine oxidation to generate ROS (O 2 - ) while depleting GSH, weakening antioxidant defenses [140]

The p K a of the histidine imidazole group is 6.5, and thus histidine behaves as hydrophobic residue at neutral pH, whereas it is protonated and behaves as a basic peptide in the slightly acidic endosomal milieu

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Example: If your doc reviewed your blood work and saw elevated Test or bioavail Test above the high range, would they alter your TRT dose