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Increased activity at the 5-HT1A receptor is linked to mood regulation, often being associated with anxiolytic and antidepressant effects

-Vitamin B2 (Riboflavin) Promotes healthy skin, eyes, and cellular energy production

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Recall that the 16-OH-E1 estrogen metabolites are proliferative (cause tissue growth), thus, anecdotally we see elevated 16-OH-E1 levels associated with proliferative conditions such as heavy bleeding, breast tenderness, endometriosis, and fibroids