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428 Peripheral nociceptor terminals respond to noxious stimuli via an array of receptors and ion channels to initiate an action potential

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So, while the debate between localized and systemic application will likely continue, the most consistent and logically sound approach for targeted ankle research points toward a localized, subcutaneous injection near the site of injury

They may also promote joint healing and mobility by delivering anti-inflammatory or regenerative substances directly to the affected area

According to a study by the Journal of Applied Physiology, BPC-157 has been shown to promote tendon healing