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1 Steady-state concentrations are reached after roughly five weeks of once-weekly dosing, with substantial carryover from one week to the next
After 36 weeks of tirzepatide on an open-label lead-in, participants who switched to placebo regained approximately two-thirds of their lost weight by week 88
DOI: 10.1038/srep31788 [Google Scholar] Wu YC, Wang WT, Lee SS, Kuo YR, Wang YC, Yen SJ, et al
Nucleoside analogues Nucleoside analogues are chemically similar enough to nucleosides to be incorporated into growing DNA strands, but different enough to ensure that the resultant DNA is non-functional