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99,219 In excitatory neurons, CaMKII functions as a shuttle molecule to collect Ca 2+ /Calmodulin from the cytoplasm and transport it to the nucleus, where Ca 2+ /Calmodulin release activates CaMKK and its substrate CaMKIV to further phosphorylate CREB, thereby participating in the regulation of transcription and translation

In addition, multiple-alignment analyses demonstrated the presence of a considerable degree of conserved residues in main sites of both enzymes

NNMT is an enzyme expressed in adipose tissue, the liver, and other tissues

179 Abell, A

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