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Micromolar (M) concentrations for peptides evaluated in the in vitro immunogenicity protocol (IVIP) assay are provided in Table 2 , below (data for impurities evaluated at 0.2 g/mL is provided in Supplementary Figure S4 )

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Moreover, certain metabolic effects of diuretics observed in animal models or humans, such as glucose intolerance (Zatuchni and Kordasz, 1961