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Handling and Storage Recommendations Store unopened vials at 28 C, with 20 C recommended for long-term storage Protect from light and moisture After reconstitution, store solutions at 28 C and use within laboratory-defined timeframes Avoid repeated freeze-thaw cycles Follow standard laboratory safety, labeling, and handling procedures All handling and storage are carried out within laboratory research environments

Preliminary results from a study conducted with pregnant beef cows in late gestation reported increased maternal plasma MET concentrations in cows fed RPM and lower concentrations in those supplemented with GAA, with intermediate values in cows receiving both RPM + GAA (Motta et al., 2025), highlighting the role of GAA as a methyl consumer

Also, animals fed a high-fat diet have been shown to have increased OxS and dysfunctional mitochondria (136)

doi: 10.1016/j.nbd.2013.01.006 126 ChauhanAChauhanV