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Semaglutide (Wegovy) is approved as a weight-loss medication and an obesity treatment under certain brand names, and is also used to manage blood glucose levels in patients with diabetes

Inflammatory markers such as IL-2, IL-6, IL-7, IL-10, IL-18, interferon (IFN)-, monocyte chemoattractant protein (MCP)-1, MCP-3, and macrophage-inflammatory protein-1 have been associated with symptom severity [54-56]

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In some circumstances the lactic acidosis observed in patients treated with metformin may not be due to metformin but rather to underlying clinical disorders such as severe sepsis