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Endothelial-specific PCSK5 promotes cardiac repair following MI To investigate the role of endothelial-specific PCSK5 in cardiac repair after MI, the endothelial-specific Pcsk5 inducible knockout mice ( Pcsk5 ECKO ) were generated by crossing transgenic mice expressing Cre recombinase specifically in ECs ( Cdh 5-CreERT2) mice with Pcsk5 flox/flox mice

In particular, ER UPR-mediated activation of JNK has been linked to the development of insulin resistance and diabetes by inhibition of insulin receptor signaling (131)

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Several GLP-1 receptor agonists have shown significant reductions in alcohol consumption in animal models of alcohol addiction

DB3 Database: tissues.jensenlab.org, protein expression prediction