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42 Mechanistically, SGLT2 inhibitors improve hepatic steatosis through multiple pathways, including the reduction of circulating inflammatory and oxidative stress conditions

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Aconitase is highly sensitive to inactivation by superoxide because of its labile iron atom and its proximity to the superoxide-generating electron transport chain

Disturbed cholesterol metabolism spurs sphingolipid accumulation, down-regulates SLC7A11, curbs glutathione (GSH) synthesis and sensitizes retinal cells to ferroptosis