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Semaglutide is a GLP-1 receptor agonist (glucagon-like peptide-1 receptor agonist)

Based on this assumption, Ile 12 could be replaced with Leu or Val and retain the same effect

Future translational strategies should prioritize two directions

Several significant metabolite-microbe relationships were also revealed, including the glycine strong positive association with Clostridium (Zhuang et al., 2018) and homocysteine positive correlation with Lachnospira , Clostridium , and Haemophilus and its negative correlation with Corynebacterium and Lachnospiraceae (Zhuang et al., 2018)

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