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These findings underscore the importance of investigating not only the direct effects of cannabis, but also its broader influence on patterns of tobacco initiation and dependence. Tobacco smoking has been considered a gateway to cannabis use since the 1970s when smoking was much more prevalent and when almost all people who used cannabis had smoked tobacco first

The increased odds persisted when people with preexisting cardiovascular diseases were excluded and when shorter exposure periods prior to the cardiovascular event (eg, within 0-15 and 16-30 days of cardiovascular event) were considered. Why Would Gout Flares Trigger Heart Attacks and Strokes