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Statements Author contributions ML: Writing original draft, Writing review & editing, Visualization, Investigation

Commonly used in studies of telomere biology, oxidative-stress defense, cell-cycle checkpoints, and immune-senescence in fibroblast, epithelial, and lymphocyte assays

TNF mediates the sustained activation of NRF2 in human monocytes

Tools like DrugPatentWatch are indispensable for identifying the Patent Cliffthe precise moment a drug loses exclusivity and becomes open for generic competition or 505(b)(2) modification

These blockbuster drugs straddle the boundary: while they provide medical benefit in improving chronic conditions, they are dispensed and self-administered, fitting the pharmacy model