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However, the Asia-Pacific region is expected to show the fastest growth in the coming years, driven by increasing mental health awareness and rising disposable incomes in countries like China and India

Neuroendocrinology 50:489-494 Kern A, Grande C, Smith RG

The International Journal of Dermatology published a systematic review of the risk factors of patients with exogenous ochronosis due to hydroquinone as highlighted below

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This reduction in NAD + was accompanied by decreased SIRT1 mRNA levels, suggesting that SYNCRIP may regulate both the abundance and functional capacity of SIRT1 (Figure S4I)