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Table 3 Preclinical studies on the immunology effects of treatment targeting the gut microbiome

This is particularly concerning for fair-skinned patients because it can interfere with skin cancer screening

Figure 1 Ketogenesis might be another potential mechanism reducing GLP-1 secretion induced by a high-fat diet, as found by culturing primary intestinal endocrine cells in mice, where ketone bodies can inhibit approximately 40% of basal GLP-1 secretion (42)

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tirzepatide, sold as Mounjaro and Zepbound, as well as Lilly's Trulicity, or dulaglutide, and Novo's older liraglutide, sold as Saxenda and Victoza