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12 Epigenetic Regulators 12.1 Phase 2 12.1.1 Lamivudine (3TC) Lamivudine is a reverse transcriptase inhibitor approved for use for the treatment of HIV

Rimonabant, the first selective central cannabinoid (CB1) receptor antagonist, was not approved by the FDA because of concerns regarding psychiatric adverse events including depression, anxiety and suicidal ideation [20]

We evaluated for weight loss as a known non-behavioral side effect of MT-II, since stimulation of the MC4R system has been linked to suppression of appetite