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Furthermore, GST fusion proteins are susceptible to TG2-mediated aggregation, independent of the specific fused protein that is used

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People with CKD tend to have low vitamin D levels, which lowers the bodys ability to absorb calcium

Kidney-targeted delivery systemssuch as PEGylated lipid nanoparticles (LNPs) modified with renal tubular cell-targeting ligands (e.g., vitamin B12, which binds to cubilin on PT cells)have shown promise in preclinical studies, increasing renal Fer-1 accumulation by 510-fold and reducing systemic toxicity