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Allergic reactions such as rash, rapid pulse, changes in the taste of food and beverages, acute pancreatitis and thyroid tumors have also been reported as rare effects .

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& Nijkamp, F

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The metformin concentration in the jejunum peaks at 500 g/g, 30300 times greater than plasma concentrations [13], highlighting the small intestine as an important site of metformin uptake

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