SURMOUNT 1, 3 and 4 enrolled patients without diabetes, aged 44-48 years, mostly females, with a mean BMI of 38.038.6 kg/m 2
It only shows Lilly-sponsored studies, but since retatrutide is exclusively a Lilly compound, that limitation does not matter here
washout Timeline 1: Immediate switch (most common) Day 0: Last Wegovy injection Day 7: First Zepbound injection (2.5 mg or higher per provider instruction) Day 14: Second Zepbound injection Weeks 5, 9, 13, etc.: Dose increases per titration schedule This approach maintains continuous GLP-1 receptor agonism
Every 12 weeks thereafter: Serum copper, ceruloplasmin, hepatic panel
Within the wider GH secretagogue landscape, the GHRH-analog lineage followed a distinct regulatory arc, illustrated by the tesamorelin history