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This variation between studies may be due to the different puff routines used to generate the tobacco smoke (HCI vs ISO), aging of smoke particles over the puff routine (4 vs 8 mins) and dilution ratios in the smoke bags (75 vs 33)

Nicotine and Tobacco Research 2025: volume 28, issue 2, pages 213 to 222

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In it, Ipsen concludes that Italian smokers in the period under review should and could have known about the health risks associated with cigarette smoking, as well as its addictiveness (232)