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There are concerns that the supplement might increase the risk of death

The results indicated that the inhibitory effect of arbutin on the viability of melanoma cells is significant, while that of glutathione and EF-5 is not (Supplemental Figure S4)

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The sample size was selected in accordance with previous studies using comparable models and endpoints, which reported adequate statistical power to detect treatment-related differences while minimizing animal use in compliance with the 3Rs principle 32

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