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The problem was its short half-life natural GLP-1 is rapidly degraded by the enzyme DPP-4, making it unsuitable for therapy in its native form

5,13 Clinical trials in obesity and non-alcoholic fatty liver disease suggest that multi-strain probiotic formulations can modestly improve anthropometric measures, lipid profiles, and, in some studies, increase GLP-1 concentrations

improvement of glucose sensitivity of resistant pancreatic beta-cells

Iron dyshomeostasis links obesity and neurological diseases