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The American Cancer Society recently highlighted the role of our flagship smoke-free product in the rapid decline in cigarette sales in Japan, which has seen its rate of decline in cigarette sales quintuple from a 2 percent decline per year from 2011 through 2015 to a 10 percent decline per year from 2015 through 2018, all without a major change in national tobacco control policy

Lammel noted that drugs that block the alpha-7 nicotinic acetylcholine receptor might not work as a treatment for tobacco or nicotine addiction because they would block many necessary functions of the receptor

Association between vmPFC gray matter volume and smoking initiation in adolescents

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Michigan State University