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Semaglutide downregulates the transcription factor PPARG, thereby reducing its inhibition of the downstream molecule ACSL1, leading to increased ACSL1 expression and promoting M1 polarization, ultimately enhancing the anti-tumor effects [95]

The American College of Obstetricians and Gynecologists (ACOG) emphasizes individualized treatment plans that consider the patient's age, symptom severity, fertility desires, and treatment preferences