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Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: therapeutic implications

Vitamin B12 Function

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The Ecuadorian Laron and Brazilian Itabaianinha cohorts with congenital mutations in the GH and GHRH receptors, respectively, both provide a unique and arguably the purest examples to evaluate the effects of chronic severe IGF-I and both severe GH and IGF-I deficiency, respectively, with severe hypoinsulinemia being the common denominator in both cohorts (151, 152) ( Table 1

For instance, in Cogans syndrome the immunoglobulin G (IgG) immunoglobulins have an affinity for a supporting protein in the sensory epithelia of the inner ear Density-Enhanced Protein tyrosine phosphatase-1 (DEP-1/CD148) as well as connexin 26 that results in sensorineural hearing loss in mice [58]