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Oncotarget (2017)

SGLT2is reduce oxidative stress by activating SIRT1/AMPK and inhibiting Akt/mTOR, thus collectively contributing to improved cellular energy efficiency, increased resistance to oxidative damage, and ultimately cardio- and renoprotection (reduced blood volume and blood pressure, promotion of diuresis and natriuresis, and glycosuria), especially beneficial in HF cases where excessive fluid can place additional strain on the heart [96,97]

[10] Fat-free mass includes muscle, bone, organs, and water

GLP-1 medications are a class of treatments that help regulate blood sugar, improve insulin signaling, and support appetite regulation

Start with one or two changes, and build from there