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Since 2023, there has been a worldwide shortage of GLP-1 receptor agonists, which is expected to continue until late 2024 [71]

While others have utilized droplet microfluidics-based approaches to link the heavy and light chains from a single BCR and build natively paired scFv libraries, few of these previous efforts have bioinformatically and experimentally validated the degree of native pairing 16 and the composition of antigen-specific clones within these in vivo-derived repertoires 19