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8 The impending entry of generics in 2026, the legislative pressure of the IRA, and the pricing caps introduced by the Trump administration signify the end of the uncontested era for GLP-1 blockbusters

British Medical Journal

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Xie F, Zhang H, Dai X, Tu M, Yu C, Liu L, et al

That limitation matters because cross-trial comparisons can be distorted by: different baseline populations different dose-escalation schemes different trial duration different background lifestyle support different endpoint definitions So while it is fair to compare mechanisms and published patterns, it is not rigorous to declare a final winner