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Frequently Asked Questions Is it safe to take spironolactone and Ozempic together

This is the question most patients do not think to ask, and it is where the real nuance lives

Therefore, both chronic and acute sodium depletion, whether induced by diuretics or other medications, such as antidiabetic SGLTs inhibitors (Koh et al., 2023), may contribute to the worsening of metabolic disturbances

Especially in view of the frequent adverse effects leading to discontinuation, more knowledge on efficacy, safety, and tolerability is surely needed before their introduction in the clinical practice against T2D or obesity