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The dysesthesia signal in retatrutide, while mild, is an example of a novel side effect that wasn't seen with simpler agonists

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The OSLER test also showed increased sleep latency with exenatide treatment (37.7 1.7 min) compared to baseline (32.1 1.7 min) or placebo (29.1 1.7 min), indicating reduced objective sleepiness [88]

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According to research published in the British Medical Journal, its generally reversible within 6 to 12 months after a person stops using anthraquinone-containing laxatives

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