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MRGPRX2 is not antagonized by classical opioid receptor antagonists such as naloxone (Lansu et al, 2017), nor does naloxone antagonize morphine-induced histamine release in patients (Baldo & Pharm, 2012)

There is preliminary data suggesting that methylcobalamin by itself can cause an increase in SAH, leading to incomplete reconstitution of the methionine cycle

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