[9] Tirzepatide (Mounjaro) is recommended by NICE (TA820) for adults with type 2 diabetes
C.PaJ.KukullW.BeeklyD.KuzmaA.GangadharanP.et al (2017)
Funding This work was supported by the National Key Research and Development Program of China (2019YFE0108200), Sichuan International Science and Technology Cooperation Project (2022YFH0023), Science Popularization Base Project of Chengdu Science and Technology Bureau (2022-GH03-00003-HZ), West China Hospital 1.3.5 Project for Disciplines of Excellence (21HXFH002), West China Hospital Hospital-Enterprise Cooperation Clinical Research Innovation Project (2021HXCX04), and the National Natural Science Foundation of China (82001728)
Based on the literature, ligands of the transferrin, insulin and leptin receptors, and low density lipoprotein receptor-related proteins (LRPs) are used to shuttle pharmaceutical agents across the BBB in preclinical studies [18, 28]
Of note, GLP-1 RAs are not recommended for patients with T1DM
