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Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rdmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Frster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, ODonnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Results from randomized clinical trials have shown that daily intake of 1000 mg of metformin among 50 patients, for 3 months can alleviate oxidative stress and restore antioxidant capacity in newly diagnosed T2DM patients (Mirmiranpour et al., 2013)

Acetyl-L-Carnitine (ALC) is a modified amino acid that supports cellular energy production by assisting in the transport of fat into the mitochondria where it is converted into ATP (cellular fuel).* ALC is a highly bioavailable form of carnitine that can cross the blood-brain barrier, where it helps to neutralize free radicals, supports mitochondrial function and helps to maintain normal neurotransmitter activity.* Clinical studies suggest that ALC helps to maintain optimal neurological health.*