Il est de plus en plus reconnu que le TSA pourrait tre associ au stress oxydatif par plusieurs mcanismes, y compris le mtabolisme anormal (la peroxydation lipidique ) et laccumulation toxique despces ractives de loxygne ( ROS )
Therefore, targeted enhancement of the GSH system along with prevention of ferroptosis in the myocardium is a promising therapeutic strategy
Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in mice
Berman E, Arlin Z, Daghestani A, Gee T, Kempin S, Mertelsmann R, Andreeff M , Hancock R, Baratz R, Williams L, Clarkson B, Young C
Conversely, inhibiting TLR4 can suppress microglial activation, alleviate neuroinflammation, improve cognitive function, and mitigate synaptic plasticity impairments and depression-like symptoms via this pathway (159, 160)