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NADH/NADPH as the electron donor in ROS generation Major endogenous ROS via superoxide radicals is constantly produced by both non-enzymatic reactions such as the mitochondrial respiration that needs NADH and enzyme-catalyzed reactions including NOXs that require NADPH

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Participants randomized to retatrutide initiated treatment with 2 mg once weekly and increased the dose in a step-wise approach every four weeks until reaching the target dose of 9 mg (via steps at 2 mg, 4 mg and 6 mg) or 12 mg (via steps at 2 mg, 4 mg, 6 mg and 9 mg)