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335 Moreover, androgens decrease the type I muscle fibers (TIMF) with highly oxidative and insulin-sensitive properties, while increase type II muscle fibers (TIIMF) that are glycolytic and less insulin-sensitive, further decreasing glycogen synthase expression and favoring the development of IR in PCOS

In fact, one study suggests that GLP-1 therapies can influence skin biology, including epidermal thickness and barrier function. Thats where skincare comes in

GLP-1 medications are prescription-only

This may raise GLP-1 levels by helping your gut make SCFAs like acetate and butyrate

However, patients should establish medication tolerability before committing to extended packages, particularly given current supply uncertainties