tirzepatide and liver enzymes for MASH with Fibrosis A Comprehensive Review of Metabolic

Acknowledgements Cristian-Daniel Llach received the support of a fellowship from la Caixa Foundation (ID 100010434 - fellowship code LCF/BQ/EU22/11930062)

However, when combined with insulin or sulfonylureas, the risk of hypoglycaemia increases significantly, and dose adjustments of these medications may be necessary

The benefit of GLP-1 RAs exceeded the harms for weight loss in the first 2 years of treatment, yet the net benefit was dependent on individual treatment goals (10% or 5% weight loss) and willingness to accept harms in pursuit of weight loss

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