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The suspicion is that some people with a mutation that affects a neurotransmitter (possibly in the COMT gene) can feel quite horrible when a strong methylating agent is introduced to the body

Several medical conditions are well known for causing these symptoms

Protein thiols undergo reversible and irreversible post-translational oxidative modifications such as, via the direct reaction with H 2 O 2 that results in various oxidation states of cysteine residues including, sulfenic (SOH), sulfinic (SO 2 H), or the irreversible sulfonic acid (SO 3 H) [[24], [25], [26]]

Mice aged 1224 weeks and sex-matched were used for all experiments