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For the purpose of randomization following the 2-week run-in with the 21-mg nicotine patch, quit status will be determined by participants self-reported 7-day point prevalence abstinence (PPA), defined as no smoking, not even a puff, for the past 7 days

Pregnancy: nicotine sensitivity often increases during pregnancy (oestrogen-induced CYP2A6 upregulation produces faster nicotine metabolism but more side effects)

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Common causes include: Eustachian Tube Dysfunction The most frequent culprit behind ear fluid is a Eustachian tube that isnt opening and closing properly

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