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In addition, MYC, a transcription factor that improves sensitivity to apoptosis stimulation, is upregulated, along with the activation of other apoptotic pathways, 26,124,125 causing irreversible damage or even death of cells

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The substitution of carboxamide at the alkyl terminal (KL2, KL4 and KL5) or removal of the nitrile group from the dihydropyridine ring (KL6) moderately reduced their adjuvant activity (Extended Data Fig