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J Anal Toxicol (2023) 47:73745
Another possible reason is that severe nicotine dependence may accompany with intense pleasure, which may act as a protective role for the brain volume. The study continued: This current study confirms that brain volume atrophy appears to be more serious in smokers with higher levels of cigarette consumption and in smokers with moderate nicotine dependence, and nicotine dependence displayed contrary patterns on the brain volume of smokers compared with tobacco consumption
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