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PMID 33053716

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Furthermore, for the efficient transporter-mediated permeation across the BBB, the prodrugs must be able to bind also to the intracellular substrate binding site of the transporter at the abluminal membrane of the brain capillary endothelial cells and to be translocated out of the endothelial cells into the ECF and, subsequently, to the brain parenchyma through the targeted transporter (Figs

Dopaminergic neurons are the core factories responsible for producing dopamine (DA), an unstable neurotransmitter that can cause oxidative toxicity in the iron-rich substantia nigra environment