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The characteristic changes of GLP-1 face include 4,5 : Facial volume loss, particularly in the midface Periocular hollowing and periorbital volume depletion Dermal thinning with loss of collagen and elastin fibers Decreased skin elasticity leading to redundant skin folds Accelerated appearance of aging As a result of these facial changes, GLP-1 agonist medications can result in an older, haggard and tired looking appearance

It has become the focus of intense pharmaceutical development, resulting in numerous FDA-approved drugs for diabetes and obesity

Shortness of Breath : Not getting enough oxygen to body tissues

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Vitamin D has been shown to suppress NOX expression and activity, particularly NOX2 and NOX4 isoforms, in endothelial and vascular smooth muscle cells