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The two compounds engage GH biology from opposite directions: AOD-9604 is downstream of GH release a fragment that retains specific GH biological activity (lipolysis) without engaging GH receptors Tesamorelin is upstream of GH release a GHRH analog that prompts the pituitary to release endogenous GH Origin Comparison This is a fundamental distinction

Psychiatry 45, 5463

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The altered homeostatic incretin levels in PAR2-G37I or PAR2-R38E versus WT mice were not caused by apparent changes in metabolism, as no significant differences in food and fluid intake, energy expenditure, respiratory exchange ratio, or locomotor activity were observed in indirect calorimetry (Supplemental Figure 2, A and B)