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The two forms of glutathione coexist in the body and form what is known in scientific jargon as a redox couple or GSH/GSSG couple

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Upon recruitment to neoplastic sites or differentiation from resident populations within the tissue of origin, these macrophages undergo phenotypic reprogramming specific to the tumor microenvironment, resulting in discrete tumor-associated macrophage subpopulations

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e-mail: [email protected] This article was submitted to Frontiers in Neuropharmacology, a specialty of Frontiers in Neurology